Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-PHENYL THIOSEMICARBAZIDE DERIVATIVES AS ANTIINFLAMMATORY AGENT

Ayush Singh*, Navjot Singh and Shweta Singh

.

Abstract

Thiosemicarbazides derivatives were synthesized by reacting 5-chloro- 2-hydrazinylbenzo [d]oxazole and substituted phenyl isothiocyanate then characterized for Molecular formula, Physical state, Color, Melting point, Yield, Solubility and Rf – value. Structure of synthesized Thiosemicarbazides derivatives were elucidated using spectrogram data as well as physical method e.g. Elemental analysis, FT-IR, 1H NMR and mass. Moreover, synthesized compounds characterized by the TLC and melting point. In addition, by visual inspection synthesized compounds also characterized. Novel synthesized Thiosemicarbazides derivatives were evaluated in- vitro for anti-inflammatory activity by kit available in market estimate the inhibition of Cox-1 and Cox-2 activity. Novel synthesized Thiosemicarbazides derivatives TSCZ-5 was exhibited excellent antiinflammatory activity against COX-1 & Cox-2 with IC50 value less than

Keywords: 4-phenyl Thiosemicarbazides, anti-inflammatory, Cox-1 and Cox-2.