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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

HEPATOTOXIC EFFECT OF ARTESUNATE, AN ANTIMALARIAL DRUG IN WISTAR ALBINO RATS

Ranjita, Jahas J, Rao SN, Shyamjith Manikkoth*

Abstract

To study the effect of artesunate, the antimalarial drug on liver in Wistar albino rats. Methods: Artesunate was administered at a dose of 36, 72 and 110mg/kg body weight intraperitonially respectively for 14 days in Wistar albino rats. The effect of artesunate on liver was assessed based on biochemical and histopathological analysis. Results: The results disclosed that on artesunate administration at a dose of 110mg/kg body weight for 14 days caused a significant increase (p

Keywords: Artesunate, Liver injury, Wistar albino rats.

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