Abstract

A REVIEW ON ANALYTICAL METHOD FOR DETERMINATION OF NETUPITANT AND PALONOSETRON IN PHARMACEUTICAL FORMULATION

Syeeda Juveria Aijaz* and S. H. Rizwan

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Abstract

Nausea and vomiting are the important adverse reaction/effects of Chemotherapy that effect the treatment as well as the health related quality of life. A FIXED combination of Netupitant and Palonosetron is use in the prevention of acute and delayed Chemotherapy-induced nausea and vomiting (CINV). This drug’s, clinical and pharmaceutical analysis requires effective analytical procedures and stability studies. Netupitant is a highly selective neurokinin-1 receptor antagonist and Palonosetron is a serotonin 5-HT3 receptor antagonist with a distinct pharmacological profile. It also exhibits prolonged efficacy to provide significantly better protection from nausea and vomiting (CINV). This review paper presents an overview of analytical and chromatographic methods reported for the analysis of Netupitant and Palonosetron in pharmaceutical formulations.

Keywords: Netupitant, Palonosetron, CINV, Analytical methods.