Abstract

THE IMPORTANCE OF PHARMACOSOMES IN NOVEL TARGETED DRUG DELIVERY SYSTEM: REVIEW

Prof. Dr. S.A. Azeez Basha, Amtul Hajera*, Md. Abubakar and Afreen Sultana

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Abstract

Several issues are encountered in the field of solubility augmentation. Pharmacosomes are a revolutionary technique based on a lipid drug delivery mechanism. Pharmacosomes are colloidal, nanometric-sized micelles, vesicles, or hexagonal assemblies of colloidal drug dispersions covalently bonded to the phospholipid. The drugphospholipid complex is appropriate for oral delivery since it is biodegradable and non-toxic, allowing it to be used as a solubilizer, emulsifier, and matrix forming excipient for drugs with low solubility and/or permeability. The current review summarises the recent developments about pharmacosomes and the mechanisms by which they improve drug bioavailability. It also includes information on pharmacosome formulation and preparation processes, as well as characterisation techniques. The rising number of recent research addressing the use of drug-phospholipid complexes to improve drug oral bioavailability demonstrates how important this method is for successful oral delivery.

Keywords: Oral bioavailability; phospholipid; drug-phospholipid complex; pharmacomes; preparation; characterization.