Abstract

GENOTOXICITY: MALIGNANCY, DAMAGE TO DNA; A VOLUMINOUS REVIEW

Bhujbal Akshay E.*, Shingne Snehal S., Proff. Santosh Waghmare and Dr. H. V. Kamble

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Abstract

A chemical agent that causes DNA damage is genotoxin. Germline mutation, somatic mutation lead to malignant transformation. The invivo, in-vitro test is performed for genotoxicity. The various assay is helped to detect DNA damage and is also used to evaluate the safety of environmental chemicals and to know the mechanism of action of suspected carcinogens. Many mutagens undergo metabolic activation for binding with DNA and DNA adduct in a reactive species can be detected in cells and human tissues by using various sensitive techniques. The characterization and the detection of DNA adducts provide causes of human cancer.

Keywords: Carcinogens, mutagenicity, DNA adduct, immunoassay, genotoxin.