Abstract

RECENT ADVANCES IN VESICULAR DRUG DELIVERY HIGHLIGHTING NIOSOMES

Syeda Aiman Faheem* and Abdul Mannan

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Abstract

A broad variety of medications, including doxorubycin, vaccines, insulin, siRNA, and other therapeutical agents, may be delivered through Vesicle delivery systems (VDDS). Due to excellent chemical and physical stability, comparatively smaller dimensions etc. they may be employed for the transport of genetic materials. Lipoplex is a commonly utilised suppliers of genes that may induce in vivo circulatory toxicity and non-specific attachments. VDDS may also be utilised as vectors for DNA vaccinations and provide a simple, stable and economical option as opposed to liposomes. It is also discovered that DNA encoding surface antigens of hepatitisB (HBsAgs) could be encapsulated and triggered an immunological response to the production of serum antibodies and endogenous cytokines by utilising niosomes as gene carriers.

Keywords: Vesicle delivery systems (VDDS), niosomes, DNA encoding surface antigens.