Abstract

ROLE OF PESTICIDES IN THE PATHOPHYSIOLOGY OF PARKINSON’S DISEASE AND ITS AYURVEDA PERSPECTIVE

Vallari Pujari*, Geetha B. Markande and Prashanth Jain

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Abstract

Background: A person’s genetic makeup is likely more important in determining whether he or she develops Parkinson’s disease than any environmental risk factor. PD is a neurodegenerative disorder, affecting greater than 1% of the worldwide population over the age of 65 and is the fourth most common neurological degenerative disorder found in the elderly. Environmental factors have been shown to contribute to the incidence of PD. Pesticides, which represent one of the primary classes of environmental agents associated with PD, share the common feature of being intentionally released into the environment to control or eliminate pests. There is a strong bond between the pesticides and the occurrence of Parkinson’s disease. Methodology: All the available information was collected from available text books and digital sources. Discussion: Kaphavruta vyana shares the same platform with the Parkinson’s disease in majority of the time. The concept of cumulative toxicity (Dushi Visha) of Ayurveda says about slow acting poison which are not been completely eliminated out of the body. After retaining for a longer period of time in the bodily tissues, this latent poison does contamination. The route of entry of these harmful substances, after entering into the body, accumulates and not eliminated from the body. This accumulation at the level of system does the chronic poisoning and related symptoms too, which are seen on both body and mind. Conclusion: Parkinson’s disease is caused by combination of factors. Better understanding of complex genetic, environmental, aging and other factors lead to Parkinson’s would be a game changing in our pursuit of preventive and therapeutic options. The study Parkinson’s disease under the pathology of cumulative toxicity may provide a new lane in the treatment aspect.

Keywords: Parkinson’s disease, neurodegenerative, Kaphavruta Vyana Vata, Dushi visha, Cumulative toxicity.