Abstract

EFFICACY OF TOPICALLY APPLIED H2 RECEPTOR ANTAGONIST GEL IN SUBJECTS WITH GENERALIZED CHRONIC GINGIVITIS

*Dr. Anamika Sharma, Dr. Apeksha Ghai and Rupesh Tiwari

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Abstract

Inflammatory disease affecting the gingiva is prevalent in individuals of all age groups. It is caused by microorganisms such as porphyromas gingivalis, tannerella forsythia and treponema denticola that reside in the gingival sulcus and cause gingivitis. Every individual responds differently to these pathogens depending on their immunity and the virulence power of the bacteria. Scaling and Root Planing procedures do not eliminate the bacteria alone. Therefore, host modulative agents are used as an adjunct to the non surgical therapy. These immunomodulative agents suppress the proinflammatory mediators to produce a therapeutic effect. Histamine exerts certain effects on cells which are opposed by H2 receptor antagonists. These receptors also obstruct the process of inflammation.

Keywords: Gingivitis, Histamine, H2 Receptor Antagonists, immunomodulation, mast, cells, gel, ranitidine.