Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLETS OF AN ANTI-DEPRESSION DRUG

Mahendra Singroli*, Rahul Sharma and Jagdish Chandra Rathi

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Abstract

The concept of formulating fast dissolving tablets containing Imipramine offers a suitable and practical approach in serving desired objective of faster disintegration and dissolution characteristics with increased bioavailability. Fast dissolving tablets of Imipramine were prepared by direct compression methods and blend was evaluated for the pre-compression parameters such as bulk density, compressibility, angle of repose etc. The tablets were prepared by using croscarmellose sodium, crospovidone and sodium starch glycolate, as superdisintegrants in different concentration along with microcrystalline cellulose. Total six formulations were prepared and evaluated for hardness, friability, weight variation, content uniformity, wetting time, water absorption ratio, disintegration time and invitro drug release. In-vitro dissolution studies are performed by using phosphate buffer pH 6.8 at 75 rpm by paddle method. The in vitro dissolution studies showed that Imipramine tablets formulation F6 showed maximum 95.85% over a period of 10 min. Overall the results of the dissolution rate studies indicated greater dissolution rate of Imipramine from fast dissolving tablets.

Keywords: Imipramine, Fast Dissolving tablets, croscarmellose sodium, crospovidone and sodium starch glycolate, Formulation, Development.