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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

INSILICO DESIGN, SYNTHESIS, AND ANTI-DIABETIC EVALUATION OF BENZOTHIAZOLE SUBSTITUTED OXADIAZOLE DERIVATIVES

Meenu Vijayan* and Manju P. T.

Abstract

Diabetes Mellitus is a disease of critical metabolic failure characterized by high blood glucose levels and less insulin. The objective of the study is to carry out the insilico design, synthesis and anti-diabetic evaluation of benzothiazole substituted oxadiazole derivatives. For insilico designing ACD lab Chemsketch v. 12.0, Molinspiration Online Software, Autodock Vina were used. All the designed derivatives were synthesized and characterized spectrally. The anti-diabetic evaluation was conducted by alpha-glucosidase inhibitory assay. The in-vitro antidiabetic screening revealed that only BZT4 showed inhibition against alpha-glucosidase.

Keywords: Diabetes mellitus, Alpha-glucosidase, Autodock Vina, Acarbose.

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