Abstract

FORMULATION EVALUATION AND CHARACTERIZATION OF FAST DISSOLVING TABLET OF DEFLAZACORT

Sanjay Barse*, Shikha Shingh, Nishi Prakash Jain and R. B. Goswami

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Abstract

Better compliance to the patient of osteoarthritis is a prime importance of formulation and development team, this can be achieved formulating fast dissolving tablet. Fast Dissolving tablets of Deflazacort were formulated by employing the direct compression method. The prepared fast dissolving tablets were evaluated for various parameters like weight variation, hardness, friability, disintegration time, drug content, wetting time, in-vitro drug release, and FTIR. Preformulation studies of Deflazacort drug were performed. The FTIR studies revealed that there is no chemical interaction with excipients. Percentage weight variation and drug content uniformity were found to be within the approved range of all the formulations. Evaluation parameters like hardness and friability indicated good mechanical resistance of the tablets for all the formulations. The Deflazacort FDT were subjected to various post compressed evaluation parameters and based on that, it was concluded each formulation was found to be an optimized formulation, except for F1 & F2, providing a quick onset with faster absorption, showing a better therapeutic effect.

Keywords: Fast Dissolving Tablet, Deflazacort, Osteoarthritis.