Abstract

FORMULATION AND DEVELOPMENT OF MATRIX TABLET OF THIOCOLCHICOSIDE

Punam Agrahari*, Dr. Navjot Singh and Shradha Shende

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Abstract

Thiocolchicoside has the muscle relaxing effect with antiinflammatory and analgesic effects. Since the side effects and lower bioavailability of Thiocolchicoside (25%) with half life of 3-4 hr, an effort has been made for the formulation development of matrix tablet for its oral application. Observation of organoleptic properties, solubility, melting point and partition coefficient was done. max was found at 259.5 nm by UV-Visible spectrophotometer, linearity was achieved in the concentration range of 5-25μg/ml in phosphate buffer (pH 6.8) at 259 nm. Drug-excipient compatibility was studied by Physical observation and performed on FT-IR spectra, found no incompatibility. Matrix tablets of drug were prepared by non aqueous wet granulation method. Initially the concentration of polymer was optimized to get better matrixing property and sustain release of the drug, prepared formulation H-1 to H-5 were evaluated and observed. Micromeritic properties of prepared granules were obtained all formulation batches possessed then of hardness, thickness and diameter of the tablets and weight variation, content variation friability and Swelling behavior in terms of swelling Index were optimum. The drug release study of the formulation H-1 to H-5, were showing good release but the formulation H-3 good drug release profile of 93.15±0.85. To find out the mechanism of drug released from the optimized formulation H-3 thiocolchicoside matrix tablets, the data was fitted to zero order, first order Higuchi and Peppas models of kinetics.

Keywords: Thiocolchicoside, Matrix Tablets, Organoleptic, HPMC, Micromeritic.