Abstract

SYNTHESIS AND CHARACTERIZATION OF SOME NITROGEN CONTAINING HETEROCYCLIC DERIVATIVES VIA NOVEL CHALCONES

Dr. Shrikrishn D. Tupare*

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Abstract

Chalcones have great importance in natural as well as synthetic chemistry. It is one of the wonderful precursors used for the synthesis of different 5, 6, 7 – membered heterocyclic compounds. Whereas Nitrogen atoms containing heterocyclic compounds are medicinal important due to their biological activities. After reviewing the literature survey, I found out, that nitrogen-containing five-membered heterocyclic pyrazoles have different synthetic methods & pharmacological activities. This prompted me to prepare highly stable five-membered ring structures like 1, 3, 5-triphenyl 1H Pyrazolone and its derivatives via novel Chalcones synthesized by aromatic ketones and aldehydes in alkaline medium having heterocyclic moiety. These compounds were characterized using IR, 1H-NMR, and Mass spectra and Elemental analysis. As per literature, they possess some potent biological activities. Therefore, antibacterial and antifungal activities were screened for these derivatives. most of the compounds were found to be the most active against bacterial & fungal human pathogens.

Keywords: Chalcones, Heterocyclic, Nitrogen, Pathogens, Pyrazolone, Screening.