Abstract

EOSINOPENIA IN CRITICALLY ILL COVID-19 PATIENTS: AN INDIAN MONOCENTER RETROSPECTIVE STUDY

Sunderesh Kamal Chander U., Kishore Kumar M.*, Sonti Sulochana and Yogalakshmi E.

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Abstract

Introduction: The coronavirus disease 2019 (COVID-19) pandemic is a serious public health concern worldwide. The virus mainly causes respiratory symptoms and other manifestation. Assessments showed that COVID-19 can cause various alterations in the blood parameters especially in eosinophil counts. Objectives: Our study aims to assess the diagnostic role of eosinophils count in severe acute respiratory syndrome coronavirus-2 infection at the time of hospital admission. To determine the relationship between eosinopenia and COVID-19 mortality as well as the clinical conditions that could potentially lead to mortality. Patients and Methods: A retrospective study was carried out during the period of March 2020 to March 2021 in Saveetha Medical College and Hospital, Tamil Nadu, India. Total of 350 patients with COVID-19 infection were taken for this study. Demographic data was collected from patients medical records at the time of hospital admission included medical histories, clinical symptoms, Radiological findings. Eosinophil counts was obtained from Sysmex Automated Analyzer NX1000. Results: In our study, on gender distribution out off 350 patients, 207 cases were males, 143 were female. 72 patients were admitted in critical ward and 278 were admitted non critical ward. In which eosinopenia was observed in patients admitted in critical ward and normal eosinophil counts was observed in patients admitted in non critical ward. Conclusion: Eosinopenia is an early indicator of COVID-19 infection if progressively worsening may progress to critical disease and have a significantly higher chance of mortality.

Keywords: COVID-19, eosinophil count, Absolute eosinophil count, eosinopenia and hematological parameters.