Abstract

AN OVERVIEW OF CURCUMIN AS ADJUVANT IN CANCER VACCINES

K. Yogeswaran*, B. Vanitha, S. Divya Lakshmi, A. Monica and O. Silpa

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Abstract

Cancer is a disease that caused most deaths among people. Various treatments against cancer are present these days. A new way of cancer treatment has arisen in the field of oncology that is cancer vaccines. Cancer vaccines prevent cancer and are also used to treat existing cancer. There is various adjuvant used along with the vaccine. This review aims to introduce the different modes of action of adjuvant and give insight into the types of adjuvant that possess the greatest potential for adjuvanticity. Curcumin is one of the best options that can be used as an adjuvant. Curcumin combined with the FAPαc vaccine, IDO expression, and TNF-α-induced EMT can be inhibited. Curcumin with ListeriaAT-mage-b increases the efficacy against metastases in TNBC model 4T1 through a reversal of tumour-induced immune suppression. Curcumin micelles would remodel the tumour microenvironment to improve the efficiency of the vaccine in which curcumin polyethylene glycol conjugate (CUR-PEG) and is effective in immunotherapy of melanoma. The final review shows that curcumin can be used as an adjuvant for cancer vaccines. Curcumin can also boost the treatment for cancer along with cancer vaccines.

Keywords: Cancer, Cancer vaccine, Curcumin, Adjuvant.