Abstract

ACUTE TOXICITY STUDY OF AN ANTIPYRETIC HERBOMINERAL COMPOUND: AMRUTKALANIDHI RASA

*Dr. Kaumudi Bagul and Dr. Sheela Pargunde

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Abstract

Amrutkalanidhi rasa is an antipyretic medicine mentioned in Yogaratnakara in Jwara chikitsa chapter. Purified Vatsanabha, Maricha and Kapardika bhasma are the ingredients used in the preparation of this medicine. Now a days a lot of emphasis has been given to safety and toxicity studies of herbo mineral compounds. Hence aim of current study was to study acute toxicity of Amrutkalanidhi rasa on Wistar albino rats that was carried out according to general guidelines for safety and toxicity evaluation of Ayurvedic formulations by CCRAS. Therapeutic dose in rat was 5.40 mg/kg and its 10 times dose approximately 50 mg/kg was taken as limit dose. Animals were dosed individually and observed continuously for 24 hrs for 14 days to detect any changes in autonomic or behavior responses. After 14 days representative rats from each group were sacrificed for observing pathological changes. From general observations and histopathological examination of kidney, heart and liver it was concluded that Amrutkalanidhi rasa found to be non-toxic and safer to use.

Keywords: Acute toxicity study, Wistar albino rats, herbo mineral, CCRAS guidelines