Abstract

JATROPHA CURCAS L. LEAF EXTRACT: VALUABLE NATURAL ANTIBACTERIAL FOR STAPHYLOCOCCUS EPIDERMIDIS

Sri Agung Fitri Kusuma*, Irma Erika Herawati, Maulia Herdiani and Danni Ramdhani

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Abstract

Objective: This study was purposed to determine the potential of Jatropha curcas L. leaf ethanolic extract as natural antibacterial substance to overcome skin infection caused by Staphylococcus epidermidis. Methods: The antibacterial activity of J. curcas extract was evaluated on the growth of S. epidermidis bacteria in vitro by agar diffusion method in various extract concentration of 20, 40, 60 and 80 % w/v. The minimum inhibitory concentration (MIC) value was determined with the broth dilution method with diluted concentration of 0.3125; 0.625; 1.25; 2.5; 5.0 and 10 % w/v. Results: The increased concentration of the extract displayed the bigger formation of the inhibition zones. This strongly indicated the potential of the extract as antibacterial candidate for S. epidermidis. The Jatropha leaf extract could inhibit S. epidermidis growth with a minimum inhibitory response in the concentration range of 0.625 % and 1.25 % w/v. Conclusion: These results highlight the potential of J. curcas leaf extracts as a naturally antibacterial substance suitable for skin infection treatment, mainly caused by S. epidermidis.

Keywords: Jatropha curcas L., leaf, extract, antibacterial, Staphylococcus epidermidis.