Abstract

SUMMARY BASED ON DIFFERENT ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF POSACONAZOLE IN PHARMACEUTICAL DOSAGE FORM

Sudha T.*, Nivetha S., Pavithra V., Priyadharshini B. and Priyanka V.

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Abstract

Posaconazole is pharmaceutical drug used for the treatment of fungal infection. This review is based on analytical method development and validation Posaconazole and its combination with many drugs. Several analytical methods have been carried out its estimation like UV, HPLC, LC/MS, HPLC – DAD and UHPLC – UV, Stability indicating HPLC, UPLC – MS/MS, Stability indicating UPLC, LC-MS/MS, Mass Spectrometry. An most reliable and reproducible HPLC method have been developed for estimation of Posaconazole. This review paper will be useful for future research and study purpose. It gives wide range of information about various analytical methods development and validation of posaconazole.

Keywords: Posaconazole, Antifungal, Posanol, UV Spectrophotometry, HPLC, UHPLC.