Abstract

A FUTURE TREND TOWARDS THE ENHANCEMENT OF BIOAVAILABILITY: PHYTOSOMES

Kamal Saroha, Neha Langyan*, Anamika Tanwar and Sunil Yadav

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Abstract

Plant active components (polyphenols) have limited physiological activity. The following are two key variables that influence polyphenolic component absorption and, ultimately, bioavailability: The first is that the main elements of a molecule are several rings that are not so tiny that they will be absorbed by the diffusion process. Second, because polyphenolic constituents are poorly soluble in lipid, they cannot pass across double membranes. As a result, the combination of phytolipid complexes (phytosomes) is beneficial in overcoming this type of issue and increasing the bioavailability of herbal extracts (polyphenol). There are a variety of products on the market that are a mixture of phyto and lipid in either a 1:1 or 1:2 ratio, such as Ginkgoselect phytosome, siliphos, Meriva, Quercefit, leucoselect phytosome, and others. This study provides an update on current advancements in phytosome technology, list of phytosomal drugs on clinical trial, an indena product list, patent on phytosomes, and various dosage forms of phytosomes for drug delivery.

Keywords: Phytosomes, herbal extract, phospholipid, bioavailability.