Abstract

HYDROXYCHLOROQUINE ACTION ON SARS-CoV-2 AND DRUG-DRUG INTERACTION HAMPERING NORMAL PHYSIOLOGICAL HOMEOSTASIS

Kushal Nandi, Dhrubo Jyoti Sen* and Dhananjoy Saha

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and chloroquine have garnered unprecedented attention as potential therapeutic agents against COVID-19 following several small clinical trials, uncontrolled case series, and public figure endorsements. While there is a growing body of scientific data, there is also concern for harm, particularly QTc prolongation and cardiac arrhythmias. Here, we perform a rapid narrative review and discuss the strengths and limitations of existing in-vitro and clinical studies. We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines.

Keywords: Chloroquine, Clinical trials, COVID-19, Hydroxychloroquine, SARS-COV-2.