Abstract

MYELOID BLAST CRISIS OF CHRONIC MYELOID LEUKAEMIA- A CASE STUDY

Nithya R.*, P. Sharmila Nirojini, P. Nithya Kala and C. Vaishnavi Devi

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Abstract

Chronic Myeloid leukemia is a slowly progressive disease which affects Bone marrow, where multiple White blood cells are produced. Blast crisis (BC) is still the most difficult aspect of managing chronic myeloid leukemia (CML). In chronic phase survival rate in average is considered to be 25 to 30 years. The first line therapy in chronic myeloid leukemia is Imatinib which is also a standard therapy due to its exceptional effects and mild toxicity, however in some cases the therapy may be a failure due to poor hematological response, in that case second line TKI agents are administered also in certain cases Bone Marrow Transplantation are preferred. We present a case study of a patient with chronic myeloid leukemia – Blast crisis in a south Indian hospital.

Keywords: Chronic myeloid leukemia (CML), Imatinib, Blast crisis(BC), TKI (Tyrokinase Inhibitors)