Abstract

NIMBOCHALCIN FROM AZADIRACHTA INDICA

Pasupuleti Sreenivasa Rao*, Sarvepalli Vijay Kumar, Indira Arumugam, Gundluru Aruna, Ramalinga Viswa Kumar, Shaik Sadak Basha and Mannur Ismail Shaik

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Abstract

Global population up to 80 percent, relies on traditional medicine for their primary health care. The usage of medicinal plant/herbal medicine for treating various disorders and diseases is rapidly progressing due to their less side effects. Azadirachta indica (Neem) belongs to the family Meliaceae, cosmopolitan in distribution, widely used in ethno traditional medicine. For centuries in India, it is commonly used in several native medical practices. Its vegetative parts such as leaves, flowers, fruits, seeds and bark known to possess numerous bio-active molecules, so affectionately called as store house of phytochemicals. Its chemical composure is quite complex. Few studies characterized, and separated some of the bioactive molecules and reported with substantial biological activities. However, in the present study, we identified, the presence of Dihydrochalcones like Nimbochalcin in the vegetative parts of Azadirachta indica (Neem) extracts using LC–MS (Liquid Chromatography and Mass Spectroscopy) spectral analysis. Moreover for the first time, we report the presence of major Dihydrochalcones like Nimbochalcin (C22H26O9) from the vegetative parts of Azadirachta indica collected from Tirumala Hills, Eastern Ghats, India.

Keywords: Flavonoids, Nimbochalcin Azadirachta indica, Natural products, LC –MS, (C22H26O9).