Abstract

EVALUATION OF ANTI DIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF BARLERIA MONTANA (L) WIGHT & NEES EX C.B.CLARKE LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

*GUNJI VENKATESWARLU¹, V.MAITHILI², PAJ VINEELA², K PRADEEP², CH L V EJASWINI².

¹Padmavathi College of Pharmacy and Research Institute, Krishnagirimainroad, Periyanahalli, Tamilnadu- 635205, India.
² Ba & Kr College of Pharmacy, NH-5 Vedugondalapadu, Ongole, Andhra Pradesh. India.

Abstract

Indigenous drug Barleria montana Nees in Wall used by different ethnic groups of the world for the treatment of diseases have special significance from long time like diabetes, wounds, cuts, hepatoprotective, etc. No scientific work has been carried out on the leaf of Barleria montana.The present work is undertaken to produce some pharmacognostic, phytochemical and pharmacological standards and this founding�s may help to proper identification and ensures the quality of the drug. It may help this amazing plant grown on commercial basis for better use in pharmaceutical herbal The extract of Barleria montana was done by using soxhlet apparatus with ethonal.With Ethanolic extract of Barleria montana the pharmacological actions were observed by measuring anti diabetic activity in streptozotocin induced diabetic rats. The results were tabulated accordingly. The percentage yield of ethanolic extract of Barleria montana leaves was found to be 8.56 w/w.The preliminary phytochemical studies revealed the presence ofAlkaloids,Carbohydrates,Glycosides,Gums,Phenols,Proteins,Saponins,Steroids,Fixed oils and fats(Tableno.1).The pharmacological experiments was conformed that ethanolic extract of Barleria montana has anti diabetic activity which was evaluated in streptozotocin induced rats. After inducing diabeties the standard drug Glibincimide showed blood glucose levels 257,226,195,135,116 at the dose of10 mg/kg.Where as the ehanolic extract showed 265,226,166,122,107 at the dose of 400mg/kg at intervels of 0th,5th,10th,15th and 20th day respectively.

Keywords: Herbal medicines, Streptozotocin, Glibenclamide, antidiabetic activity.