Abstract

“BETATROPHIN : A NOVEL MEDICAL ADVANCE” : A Medical Book. A Descriptive Analysis, in Clinical Research.

Dr. Moumita Hazra*

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Abstract

Betatrophin is a protein of 198 amino acids. In humans, it is encoded by C19orf80 gene. Angiopoietin-like protein (ANGPTL)8 (TD26, RIFL, Lipasin, Betatrophin), located in the corresponding intron of DOCK 6, is a newly recognised ANGPTL family member that is expressed mostly in liver and adipose tissue, and is markedly upregulated by feeding and suppressed by fasting. It has been implicated in both triglyceride and glucose metabolism. Hepatic overexpression of ANGPTL8 promotes proliferation of pancreatic β cells, causes hypertriglyceridemia, increased insulin secretion and contributes to glucose homeostasis. Co-expression of ANGPTL8 and ANGPTL3 increased plasma triglyceride level more than 10-fold, suggesting that the two proteins act together, and co-ordinate the transport of triglycerides to tissues in response to food intake. ANGPTL8, a paralog of ANGPTL3 that arose through duplication of ancestral DOCK gene, regulates post-prandial TAG and fatty acid metabolism by controlling activation of its progenitor, and perhaps other ANGPTLs. Inhibition of ANGPTL8 provides a new therapeutic strategy for reducing plasma lipoprotein levels.[1, 2, 3, 4, 5, 6, 7, 8]

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