Abstract

A REVIEW ON ETHOSOMES AS ALTERNATIVE CARRIERS CURRENTLY FOCUSING ON TRANSDERMAL DRUG DELIVERY SYSTEMS

Navaneethan S.* and Somashekhar C. N.

.

Abstract

The skin is a crucial barrier to delivering mucous/topical /transdermal medicines. Different techniques have been made to improve drug skin penetration, and vesicle carrier systems, such as Ethosomes, liposomes and niosomes, are utilized for many cosmetic chemicals. One of the latest promising methods with different pharmaceutical applications is the ethosomal drug delivery method. These are elastic Nano vesicles based on phospholipids that contain a high ethanol content (20-45%). Ethosomal carriers are soft vesicles of hydro-alcoholic or hydroglycolic phospholipids with a relatively high alcohol concentration. Theoretically, ethosomal systems are sophisticated, characterized by ease in planning, effectiveness and protection. Ethosomes can encapsulate and distribute extremely lipophilic molecules such as testosterone, cannabinoids, and minoxidil through the skin due to their unique structure and cationic drugs such as cationic drugs trihexyphenidyl and propranolol. The primary goal of the transdermal drug delivery system is Crossing the stratum corneum. This review concentrates on various aspects of ethosomes, including their penetration mechanism, preparation, structure, characterization, and implementation.

Keywords: Ethosomes, Nano vesicles, Phospholipids, Hydro-alcoholic, Hydro glycolic, Stratum corneum.