Abstract

NIOSOMAL MUCOADHESIVE GEL AS A SUITABLE DRUG DELIVRY SYSTEM FOR NASAL DRUG DELIVERY- A REVIEW

Parthiban S. and Saritha A. N.*

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Abstract

Delivery of drugs through nasal route has been potentially explored as an alternative route for administration of vaccines and biomolecules such as proteins, peptides and non peptide drugs, hence it has attracted the interest of scientific community. Inranasal therapy has been accepted form of treatment in the ayurvedic system of medicines. Nasal route is beneficial for the drugs which are unstable on oral administration because they are significantly degraded in GIT or metabolized by first pass effect in liver. Nasal route is alternative to parenteral therapy and also useful for long term therapy. Nasal mucosa is highly vascularised and most permeable giving rapid absorption and onset of action. Nasal route is non-invasive, widely used for the local treatment may also be used for systemic therapy as drug directly goes in systemic circulation. Nasal route gives good absorption of small molecules, then that of large molecules can be increased by absorption promoters. Drug targeting is a kind of phenomenon in which drug gets distributed in the body in such a manner that the drug interacts with the target tissue at a cellular or subcellular level to achieve a desired therapeutic response at a desire site without undesirable interactions at other sites. This can be achieved by modern methods of targeting the drug delivery system such as niosomes. Niosomes are the type of non-ionic surfactant vesicles, which are biodegradable, non-toxic, more stable and inexpensive. The niosomes have the tendency to load different type of drugs. In this article an overview of intranasal drug delivery with its various aspects like intranasal delivery, drug strategies to improve bioavailability and briefly about niosomes and its applications are discussed.

Keywords: Nasal drug delivery, niosomes, approaches, preparation of niosomes.