Abstract

A REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM FORMULATION AND ITS EVALUATION PARAMETERS ROLE IN DRUG DELIVERY SYSTEM

Kerryn Joseph A. D. Silva, Suresh N.*, Preethi Fernandiz and S. Srinivasan

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Abstract

Gastro retentive drug delivery is an approach to prolong the gastric residence time which helps to target the site-specific drug release in the upper gastrointestinal tract for local or systemic effects. Gastro retentive dosage forms can remain in the gastric region for long periods and hence significantly prolongs the gastric retention time of various medications. Several gastro retentive drug delivery approaches are being designed and developed which helps to retain the drug in the bottom of the stomach, low density (floating) systems that causes buoyancy in gastric fluid. Oral route of drug administration is the most preferable route due to its flexibility in formulation, ease of administration, and more patient compliance. This type of approach has certain limitations like limited gastric residence time for sustained drug delivery system and for the drugs which are absorb from specific region of gastrointestinal tract. To overcome gastro retentive drug problems various approaches have been proposed to increase the gastric retention time of the delivery system in the upper part of gastrointestinal tract. The gastro retentive drug delivery technologies includes high density (sinking), floating, bio or muco adhesive, expandable, unfoldable, super porous hydrogel, magnetic systems are is use to design the drug formulation to enhance its drug action in gastrointestinal tract.

Keywords: Gastro retentive drug delivery, gastric fluid, stomach, gastrointestinal tract.