Abstract

FORMULATION AND EVALUATION OF BUCCAL MUCOADHESIVE TABLETS OF REPAGLINIDE

Mandapati Lavanya*, Katta Manogna and T. N. Shilpa

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Abstract

Aim: The present work was performed to develop and evaluate buccal tablet containing antidiabetic drug (Repaglinide). Background: Repaglinide is poorly water soluble drug which comes under BCS Class II. By formulating as buccal tablets using polymers can enhance the solubility and bioavailability of drug in biological fluids yields therapeutic window. Method: By Direct Compression method prepared buccal tablets. Ethyl cellulose was used as backing membrane and Carbopol 934p, Polyoxwsr N-80 NF, HEC and HPC was used as bucco adhesive polymer. Aspartame was used as sweetener. Results: F5 formulations showed maximum amounts of drugs release (87.18%) at the end of 10 h dissolution study. F5 also showed maximum bioadhesion (0.0754N) and the resident time of F5 formulation was 9.2 h. It shows 41.52% drug release after 10 h permeation study through porcine buccal mucosa mounted in Franz cell. The tablet also found stable in human saliva after 10hr. The tablet was not showed any type of physical changes after the completion of 10 h. Conclusion: The results of the study suggested that new buccal tablet formulations of combined buccoadhesive polymers can be suitably developed as an alternate to conventional dosage forms.

Keywords: Buccal tablets, Carbapol 934p, Direct compression, Repaglinide.