Abstract

FORMULATION AND EVALUATION OF DOMPERIDONE MOUTH DISSOLVING TABLET

Janki Joshi*, Khushi Chouksey and Dr. Kuldeep Ganju

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Abstract

The aim of this study was to formulate and evaluate the mouth dissolving dosage form of domperidone drug as an anti-emetic drug. Super disintegrants were used for the preparation of mouth dissolving tablet namely sodium starch glycolate (SSG). The powder mixture was subjected to pre compression evaluation like FTIR, solubility studies and post-compression evaluation like friability, hardness, wetting time, dispersion time, disintegration time and in vitro dissolution rate. FTIR studies confirmed that there was no chemical interaction between the drug and excipients. The results of hardness and friability complied with the official standards. The F5 formulation showed optimum drug release of 99.5 % at the end of 25 min when compared to the other formulations.

Keywords: Dosing frequency, bioavailability, drug release, disintegration, orodispersible.