Abstract

FORMULATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY OF METRONIDAZOLE IN-SITU GELLING SYSTEM

Preethi Fernandiz, Suresh N.*, Kerryn Joseph A. D. Silva and S. Srinivasan

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Abstract

Background: Controlled release refers to the use of delivery device with the objective of releasing the drug into patient body at a predetermined rate, or at specific times or with special release profiles. Aim: To formulate and evaluate in-situ gel system for various parameters related to drug release and floating behavior. Results and discussion: FT- IR studies showed that there is no interaction between the drug and excipients. The In-situ gels shows zero floating lag time and remained buoyant for more than 12 h achieving the gastric retention properties. All evaluation parameters were within the pharmacopoeial limits. The in-vitro drug release was sustained up to 12 h. Conclusion: The studies concluded that HPMC- Sodium Alginate with the calcium carbonate of 2% in- situ gels showed a good drug release and can be used as a gastroretentive drug delivery systems in view of their swelling characteristics in acidic pH and floating in stomach respectively. It might contribute better patient compliance while reduce frequency of dosing and by acceptable sustained-release dosage forms Metronidazole in the stomach to promote a fast and effective eradication of H.pylori to cure peptic ulcer. From the viscosity analysis, In-vitro buoyancy studies and release kinetics studies it can be concluded that the formulation FA3 has better potential of sustaining drug release with good gastric retention capability.

Keywords: Gastroretentive drug delivery, Formulation, In-situ gels, Metronidazole, HPMC, Na-CMC, Methylcellulose, Sodium alginate.