Abstract

FORMULATION DEVELOPMENT OPTIMIZATION AND CHARACTERIZATION OF HYDROGEL MICROSPHERES OF LEVETIRACETAM

Indrajeet Kumar Mahto*, Rishikesh Sharma and Ajay Shakya

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Abstract

Epilepsy is a chronic CNS disorder characterized by brief episodes of seizures and excessive EEG discharge. It is usually associated with loss of consciousness, violent spasmodic contractions of skeletal muscles (Convulsions) and autonomic hyperactivity. Epilepsy is one of the most common neurological disorders. Worldwide, the prevalence is estimated to be 0.5- 1%, and there is a life time incidence of 1- 3%. The drug, excipients, and other chemicals used in this work were used as obtained from the gift sample from different companies and remains material which was used laboratory grade Levetiracetam, Chitosan, Pluronic F-127, Glutaraldehyde, n-hexane, Liquid paraffin (light), Span 80. Chitosan/Pluronic F127 was successfully used for preparation of hydrogel microspheres loaded with Levetiracetam using emulsion crosslinking method to control the release of the drug and to render oral administration applicability to the drug.

Keywords: Hydrogel Microsphere, Levetiracetam, Epilepsy, CNS disorder,