Abstract

SYNTHESIS CHARACTERIZATION & ANTIMICROBIAL ACTIVITY OF SOME NOVEL OXADIAZOLE DERIVATIES

Tanvar Maya*, Tiwari Archana, Hirve Nisha and Birle Rekha

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Abstract

In present study oxadiazole derivatives were synthesized and microbialActivity and anti inflammatory activity of different derivatives were checked with various microbial stain and rates. Various intermediates was synthesized and characterized in between time to time by chromatography and special methods. Substituted salicylic acid and diethyl malonate were starting material and finally formed 3-(-4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-oxadiazole- 2-yl)-2h-chromene-2one, while in the intermediate steps ethanol react with s Schiff base with reflex to get ethyl2-oxa-2H-Chromene-3- corboxylate, than othe intermediate fond during synthesis in 2-oxo-N- [(1E)-1-phenylethylidene]-2H-chromene- 3-carbohydrazide 2 – hydroxy-N. The structure of the entire compound was established on the basis of element, chromatography and spectral analysis. The synthesized compound was for their antimicrobial activity and anti inflammatory activity show. The compound most active be against Staphylococcus aureus, Bacillus subtillis and Carrageenan induced rat hind paw edema.

Keywords: Oxadiazole Antimicrobial, Anti-inflammatory, Salicylic acid,