Abstract

PROSPECTIVE DRUG DELIVERY BASED ON CYCLODEXTRIN NANOSPONGES

Monalisha Jena* and Dr. Manisha Karpe

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Abstract

Nanotechnology has the potential to alter the way we live in the world. Novel applications for nanomaterials are being explored constantly. Nanosponges are being designed for a wide range of applications; owing to their porosity, nanosponges can carry more medication than other nanocarriers–and they can deliver therapy predictably as required. These carriers have recently been devised and advocated for drug delivery because they can solubilise insufficiently water-soluble drugs, facilitate prolonged release, and improve drug bioavailability by modulating crucial pharmacokinetic features. Cyclodextrin-based nanosponges are a novel delivery technology comprising three-dimensional frameworks of hyper-cross-linked cyclodextrins. They produce permeable nanoparticles with diameters smaller than 500 nm, a round shape, and a negative surface charge. Additionally, they have been proven to be capable of transporting both lipophilic and hydrophilic compounds and augmenting the solubility of weakly water-soluble compounds. This review includes an overview of desirable characteristics of a prospective drug carrier, probable alterations, benefits, limitations, and a wide range of applications.

Keywords: Nanosponges, Cyclodextrin, Nanocarrier, Drug Delivery.