Abstract

FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF LAMIVUDINE USING OCIMUM BASILICUM SEED MUCILAGE AS SUPERDISINTEGRANT

Dr. M. Sunitha Reddy*, Tangella Srividyalalitha

Abstract

The objective of current study involves the formulation and evaluationof fast disintegrating tablets of Lamivudine using naturalsuperdisintegrant obtained from pericarp of Ocimum basilicum seed.Pre compression properties of tablet blend shows that the blend hasgood flow properties. Six formulations were prepared and postcompression properties shows that the formulation F2 was the bestformulation as it disintegrated within 22.79±0.01 seconds, drug releasewas 99.4±0.41% at 10minutes. It was subjected to accelerated stabilitystudies at RH 75% and 400 C for a period of one month. Theformulation was found to be stable.

Keywords: Fast disintegrating tablet, Lamivudine, Natural superdisintegrant, Ocimum basilicum seed mucilage.