Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF MEDICATED CANDY CONTAINING PARACETAMOL FOR NEONATE

Praveen Halagali*, U. B. Bolmal, Divya Prakash Jain and Rohan Singadi

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Abstract

There were so many different types of dosage forms were available in the market, but there was a need for new dosage forms which increases the bioavailability also decrease the first pass metabolism. The research work was increased to extend the bioavailability and decrease the first pass metabolism. Oral route of drug administration was the very popular method of administration of drug due to ease to ingestion, avoid the pain and most importantly patient compliance. Candy was a solid dosage form, containing medicament in a sweetened and flavoured base, intended to dissolved slowly in the mouth. Candy was medicated dosage form intended to place in the mouth of the neonate containing the paracetamol so that the candy have melted easily in the mouth of the neonate. Candy was prepared by heating the sucrose and the water and then the paracetamol drug was added to it and mix it well after that this candy solution was slowly poured on the rotator of the candy preparation machine so that the threads of the candy came out from the holes of the rotator of candy preparation machine, then candy was automatically collected and placed inside the plastic packet and sealed it. It was found that there is a no inter-reaction in middle of the drug and the sugar

Keywords: Paracetamol, Candy, Neonate.