Abstract

A REVIEW ON BIOLOGICAL IMPORTANCE OF PYRIMIDINE CONTAINS INDOLE DERIVATIVES

Muvendan C.* and Swaroopa H. M.

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Abstract

Heterocyclic molecules are frequently found in nature and are attracting increased from organic and pharmaceutical chemists. Heterocyclic compounds are acquiring more importance in recent years because of their broad pharmacological activities. Nitrogen, sulphur or oxygen containing five or six membered heterocyclic compound has occupied enormous significance in the field of medicinal chemistry. Indole is a bicyclic heterocycle consisting of a six membered benzene ring fused to a five membered nitrogen containing pyrrole ring. Indoles are an important class of heterocycles not only because they are among the most ubiquitous compounds in nature, but also because they have a wide range of biological activities. Hence, it is not surprising that indoles act as lead compounds and are key building blocks in numerous pharmaceuticals. Pyrimidine is the six membered heterocyclic organic colorless compound containing two nitrogen atoms at 1st and 3rd positions. Pyrimidines (1,3-diazines) and their fused analogues form a large group of heterocyclic compounds. Pyrimidine which is an integral part of DNA and RNA imparts diverse pharmacological properties. Pyrimidine contain Indole derivatives constitute an important class of therapeutic agents in medicinal chemistry including antihypertensive, antiproliferative, antiviral, antitumor, analgesic, anti-inflammatory, antimicrobial, antifungal activities, etc. Although pyrimidine contain indole moiety is very small but is fascinated by scientists because of the diverse biological activities. This review represents some synthesized pyrimidine contain indole derivatives and their pharmacological profiles which may contribute in future to synthesize various analogs and to develop new pharmacologically less toxic medicines.

Keywords: Pyrimidine, indole, antimicrobial, anticancer, antiiflammatory, antioxidant.