Abstract

CIPROFLOXACIN AND ITS PHARMACOKINETIC PROPERTIES

Borse Chetan*, Kumbhare Manoj, Gayke Ajit, Kotwal Sai and Kale Akshada

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Abstract

In current anti-infective therapy, Ciprofloxacin is a very popular fluoroquinolone with broad activity and diverse therapeutic prospects. The reason for its widespread use is the multidrug-resistant pathogen that is only sensitive to Ciprofloxacin. Available clinical data indicate the potential for increased effect of this drug in various treatments community-acquired and nosocomial infections, such as respiratory and urinary tract infections, skin infections, and sexually transmitted infections. Compared to other drugs in this class, the pharmacokinetic profile of Ciprofloxacin shows equal or greater bioavailability, higher plasma concentrations and increased tissue penetration, which is reflected in the larger volume of distribution. Other molecular modifications have been made to further enhance the effectiveness of this drug. Report on Multiple Methods for the Analytical Determination of Ciprofloxacin and Its Metabolites in Biological Fluids Using Different Methods. This article focuses on synthetic development, pharmacotherapeutic and analytical perspectives for the evaluation of Ciprofloxacin. Ciprofloxacin is a second-line antibiotic and a common drug. It is a very common fluoroquinolone that can treat certain bacterial infections. Quinolones are a family or group with activity against Gram-negative and positive bacteria, related to Ciprofloxacin. The primary objective of this review is to provide a complete update of the analytical methods for the determination of Ciprofloxacin and its combinations, for use in binary or triple compound endodontic treatment of primary teeth. Provided using a combination of antibacterial drugs Various techniques have been described, such as UV, TLC, GC Mass, HPLC and RPHPLC methods.

Keywords: Fluoroquinolones; Ciprofloxacin; Antimicrobial; tuberculosis; antibiotics, HPLC, TLC.