Abstract

SOLID DISPERSION: A REVIEW ON NOVEL APPROACHES FOR SOLUBILITY ENHANCEMENT OF HYDROPHOBIC DRUGS

Patel Janak B. and Patel Janki B.*

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Abstract

Solid dispersion is a strategy for improving drug solubility by encapsulating weakly water-solvent medicines in an inert hydrophilic carrier in a solid-state, which may be achieved via several methods such as melting, solvent, or solvent melting. In the assessment of solid dispersion, only a few characterization techniques have been described. This is a comprehensive review article on preparation methods for lyophilization, spray drying solvent evaporation method, hot-melt extraction, supercritical fluid, and its characterization for SEM, TEM, DSC, FTIR, XRD, and NMR in Solid Dispersion. To use solid dispersion practically and successfully, comprehensive knowledge of certain characterization techniques, its rapid release principles, methods of production, selection of appropriate transporters, and assurance of physical characteristics will be required.

Keywords: Solubility, Hydrophobic, Hydrophilic carrier, Polymer, Solid dispersion, Lyophilization.