Abstract

PREPARATION AND EVALUATION OF GLIPIZIDE MICROSPHERES USING HYDROPHOBIC BIODEGRADABLE POLYMER FOR SUSTAINED DRUG DELIVERY

Sandeep Singh* and Marina Koland

Abstract

The objective of the current investigation is to formulate ethylcellulose and eudragit based sustained release microspheres, containing glipizide as a model drug. Glipizide is generally prescribed in type-II antidiabetic drug and belongs to second-generation sulfonylureas. Due to its short biological half-life, there is an urgent need of such a delivery system which can overcome its multidosing per day through delayed release and extended half-life. Microspheres were prepared by emulsification-solvent evaporation method. Two-Two batches were prepared with different proportions of core to coat meterials (drug: polymer = 0.5:1 and 1:1 w/w). The microspheres were evaluated for various parameters like flow properties, percentage yield, drug content, particle size, surface morphology studies and in vitro drug release studies. Ethyl cellulose and Eudragit Microspheres of Glipizide were successfully prepared. Results showed that all the microspheres were found spherical in shape, having smooth surface, high percentage yield and drug content. In vitro drug release studies showed effective controlled release of drug from microspheres.

Keywords: Glipizide, emulsification-solvent evaporation method, ethylcellulose, eudragit, etc.