Abstract

PHARMACOLOGICAL EVALUATION OF POLYHERBAL FORMULATION FOR WOUND HEALING ACTIVITY IN RATS

Monika Saxena* and Kamal Kishore

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Abstract

The aim of the present study to examine wound healing activity of polyherbal formulation using Martynia annua, Aloe vera and Calendula officinalis extract. The parameters of studied included rate of wound contraction, measurement of wound index, wound area, and the period of epithelialization in excision wound model. The extracts were topically applied in the form ointment (using 6% hydroalcoholic extracts as a bioactive ingredient and was formulated in the form of simple ointment base BP) daily once times, starting from the day 1 on the excision of the rats, till complete epithelialization. In the excision wound model, the polyherbal ointment group exhibit 97.696±0.83% reduction in wound area on the 20th day when compared to control treated group which was 92.928±1.40% and faster rate of epithelialization is 21.66±0.33 days. Polyherbal ointment significantly reduced the period of epithelialization and increased wound contraction rate compared to the control group (P < 0.05). In present study reveals that the polyherbal formulation having potent wound activity which could be a good choice of remedy for wound healing.

Keywords: Martynia annua, Aloe vera and Calendula officinalis, period of epithelialization, rate of wound contraction, polyherbal ointment.