Abstract

IN SILICO STUDY OF PHYLLANTHUS AMARUS AND OSELTAMIVIR AGAINST NEURAMINIDASE

Dhanalakshmi G.* and Navya Yadav N.

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Abstract

Objective: The aim of this study is to demonstrate the antiviral activity of Phyllanthus Amarus is more efficient than the commercially available drug through In Silico docking analysis. Methods: In this study, the structure of Neuraminidase target protein, ligand molecule of P Amarus phytochemical structure and anti viral drug of Oseltamivir were collected with the help of Pubchem and PDB database. The protein – ligand based molecular docking was performed with Patchdock software and visualization of macromolecules useing PyMol. Results: The outcome of this study speculated that the lignin group of P Amarus (Phyllanthin, Phyltetralin, Niranthin, Isolintetralin, Hypophyllanthin, and Nirtetralin) possesses greater docking scores contrasted with Oseltamivir. Conclusion: This report reveals that the lignin class of PAmarus Phytochemicals can be used as ligand in the preparation of antiviral drug instead of chemical based drug preparation. This needs further confirmation by invivo and invitro studies to discover the potential drug against Influenza viral infection.

Keywords: Antiviral, Ant influenza, Neuraminidase, Molecular docking, Phyllanthus Amarus.