Abstract

FORMULATION AND EVALUATION OF CEFPODOXIME PROXETIL LOADED NIOSOMES USING TAMARIND SEED POLYSACCHARIDE

Rohit, Rajesh Manchanda and Rashmi Manchanda*

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Abstract

Non-ionic surfactant vesicles containing Cefpodoxime Proxetil were prepared using Tamarind Seed Polysaccharide, Span 60 and Cholesterol in the ratios (by weight) of 1:2:1, 1:4:1, 1:6:1, 1:8:1, and 1:10:1. The prepared vesicles were characterized for the shape, size, entrapment efficiency, and in-vitro drug release and stability studies. The particle size distributions were carried out by optical microscopic technique and spherical shape observed by TEM studies. The drug Entrapment Efficiencies varied from 76% to 86%. In vitro drug release studies were carried out by using PBS (pH: 7.4) as a dissolution medium for 24 hours. From the in vitro studies the N6 was found to be more satisfactory which exhibit a retarded release of 98.16% for 24 hours. The stability of vesicles was assessed by storage at 4 ± 1ºC and at room temperature for three month. The results suggested that the Niosomes of Cefpodoxime Proxetil using Tamarind Seed Polysaccharide can be used for Sustained release for Sustained release drug delivery system.

Keywords: Cefpodoxime Proxetil, Non-ionic Surfactant, Tamarind Seed Polysaccharide, Entrapment efficiency, Particle size, In vitro release stability studies.