Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF MEDICATED CANDY CONTAINING SALBUTAMOL SULFATE FOR NEONATE

Rahul Pokale, Praveen Halagali*, Sudeeksha Prabhu and Aparna Inamdar

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Abstract

There were so many different types of dosage forms available in the market, but there was a need for new dosage forms which increase the bioavailability and also decrease the first pass metabolism. The research work was increased to extend the bioavailability and decrease the first pass metabolism. Oral route of drug administration was a very popular method of administration of drug due to ease of ingestion, avoid the pain and most importantly patient compliance. Candy was a solid dosage form, containing medicament in a sweetened and flavoured base, intended to dissolve slowly in the mouth. Candy is a medicated dosage form intended to place in the mouth of the neonate containing the Salbutamol sulfate so that the candy could melt easily in the mouth of the neonate. Candy was prepared by heating sucrose and water and then the Salbutamol sulfate drug was added to it and mixed well. Then this candy solution was slowly poured on the rotator of the candy preparation machine so that the threads of the candy comes out from the holes of the rotator of candy preparation machine, then candy was automatically collected and placed inside the plastic packet and sealed. It was found that there is a no inter-reaction in middle of the drug and the sugar.

Keywords: Salbutamol sulfate, Candy, Neonate.