Abstract

PHARMACOLOGICAL ACTIVITY OF SELECTED MARINE SOURCE FROM COASTAL ANDHRA PRADESH

K. Swathi Priya* and Dr. S. Rajasekaran

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Abstract

Aim and Objective: The present study is to assess the acute toxicity, anti diabetic activity of hydro alcoholic extract of selected marine macro algae Spongomorpha indica (HASI). Material and Methods: The Spongomorpha indica (green macroalgae) was collected from coastal area of Visakhapatnam Andhra Pradesh. Hydro alcoholic extract of Spongomorpha indica was prepared and it was screened for acute toxicity, anti diabetic. In acute toxicity study, wistar mice were grouped into 4 and dosed wit 5,50,200,2000..mg/kg of HASI and observed at 0, 30,24hrs up to 14days. Antidiabetic activity was analyzed using two models i.e., Streptozocin induced and Dexamethasone induced. The rats were grouped into five groups each named as control, diabetic control, standard (5mg /kg Glibenclamide) and remaining two as tests with 200 and 400 mg/kg HASI were administered and results were observed. Results & Discussion: acute toxicity study showed no significant behavioral changes and LD50 was determined as 200mg/kg. In Streptozocin induced diabetic study the body weight of the normal and treated groups significantly differs from diabetic control on 14th day. Also the same urine glucose level of normal and treated groups also significantly differs from diabetic control on 14th day shown in Table 1&2 and figure 1&2. The standard (Glibenclamide (5mg/kg), hydro-alcoholic extract 200 & 400 mg/kg treated groups significantly decrease in blood glucose level on 14thday compared to negative control (Table5 and Figure4). Group II animals exhibited decreased levels of protective antioxidant enzymes such as SOD and CAT, suggesting a possible free radicals generation. Treatment with standard, HASI 200 & 400 mg/kg showed significantly (p

Keywords: HASI (Hydro alcoholic Spongomorpha indica), anti diabetic, Streptozocin, Dexamethasone, Glibenclamide.