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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF LULICONAZOLE IN BULK AND FORMULATION

S. P. Gadhwe*, V. V. Waghmare, S. J. Ithape, P. K. Ramgude, S. S. Telang and P. D. Mali

Abstract

Luliconazole is a novel imidazole antifungal used in treatment of interdigital tinea pedis, tinea cruris, and tinea corporis. A simple, precise new ultrafast liquid chromatographic method has been developed and validated for the Luliconazole in bulk and pharmaceutical dosage form. The Luliconazole had been analyzed by using RP-HPLC method using Ammonium acetate buffer: ACN at (45:55 v/v) as a mobile phase at 296 nm. The retention time was found to be 5.7 min on chromatogram. The linearity, Precision and Accuracy has been studied and found to be in compliance with official limits mentioned in ICH guidelines.

Keywords: Luliconazole, Anti-fungal, HPLC, Validation, Analysis.

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