Abstract

REVIEW: A COMPREHENSIVE STUDY ON BUCCAL PATCHES

Harsha Rameshwar Barde* and Dr. A. A. Harsulkar

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Abstract

An ideal dosage regimen in the drug therapy of any disease is the one, which immediately attains the desired therapeutic concentration of drug in plasma (or at the site of action) and maintains it constant for the entire duration of treatment. Novel drug delivery systems (NDDS) are the system where the man searches for new method of entry of drug into the body in order to show its activity in the body. The oral cavity is a captivating site for drug delivery due to ease of administration and avoidance of possible drug degradation in gastrointestinal tract and first-pass metabolism. In oral cavity, buccal region deals with an acceptable route of administration for systemic drug delivery. Delivery of drug through buccal mucosa of oral cavity is called buccal drug delivery system. This review briefly describes advantages and limitations of buccal drug delivery, anatomical structure of oral mucosa, and methodology in evaluating buccal drug delivery system, focusing on physiology, pharmacology, pathology, and formulation design in line with recent developments in buccal delivery systems.

Keywords: Buccal drug delivery system, Buccal Mucosa, Mucoadhesive, buccal patches, Buccal drug absorption.