Abstract

A SCIENTIFIC OVERVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM

Mohammed Ali and Manoj Y. V.*

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Abstract

Gastric retention and controlled drug delivery are advantageous to many drugs having a low absorption window and poor bioavailability. For that, various gastro retentive approaches are available like floating, mucoadhesion, swelling, multi-particulate systems, super porous hydrogel, etc. have been discussed. It is known that differences in gastric physiology factors such as gastric pH and motility exhibit both intra and inter-subject variability demonstrating a significant impact on gastric retention time and drug delivery behavior. Despite being one of the most successful systems, the commercial value of gastro-retentive drug delivery systems is still below par. Gastro-retentive drug delivery systems for anti-diabetic drug molecules are still awaited. The research is still in progress for gastro-retentive formulations, attracting industries utilizing these systems for humane causes.

Keywords: Gastric retention, Floating system, In situ Gel, Muco-adhesion, Controlled drug delivery.