Abstract

A REVIEW ON FORMULATION AND EVALUATION OF MICROSPHERES

Shital Andhale* and Dr. Minal Narkhede

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Abstract

Microspheres (MS), which are emulsion cells or solid particles distribute in a continued phase, have been used in various industries such as cosmetics, food and pharmaceuticals, etc. The several applications involved in microspheres are in ophthalmic Drug delivery, Oral drug delivery, Genetic drug delivery, Buccal drug delivery, Gastrointestinal drug delivery, Transdermal drug delivery, Targeting by applying micro-particulate carriers. The disadvantages of microspheres are reproducibility rate is less. The various techniques used in the preparation of microspheres spray drying, solvent evaporation method single emulsion technique, double emulsion technique, phase coacervation techniques, spray congealing and spray drying method, solvent(liquid-liquid) extraction method. Microsphere is modify using a variety of techniques which are changes in their performance and volume from management as compared to the standard management form. The different types of microspheres are bio adhesive microspheres, magnetic microspheres, floating microspheres, active radio microspheres species. Microsphere is extensively used in new drug delivery systems. One of the novel drug delivery techniques is microspheres in which the alternative treatment is more effective than standard or single unit dosage forms that are released immediately.

Keywords: Microspheres, application, types of microspheres, methods of preparation, Evaluations.