Abstract

SCREENING OF ANTI-ARTHRITIC ACTIVITY OF CRINUM LATIFOLIUM WHOLE PLANT IN WISTAR ALBINO RATS

Prof. Dr. D.V. Kishore*, Nausheen Begum*, Dr. Shaik Mohd Khasim and Dr. Sridhar Baburao

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Abstract

Phytochemicals are plant compounds that are recognised to play a key role in medicinal plants' biological activity. Because of their potential use in food supplements and medications, phytochemicals found in Crinum latifolium are gaining popularity. Its leaves, seeds, stem, and roots contain a variety of compounds that have healing benefits Rheumatoid arthritis (RA) is an autoimmune and inflammatory disorder in which your body's immune system attacks healthy cells in your body, resulting in inflammation (painful swelling) in the affected areas. Some natural therapies, when used in conjunction with conventional treatment options, may help in managing mild symptoms. Anti-inflammatory qualities in certain herbs may aid with rheumatoid arthritis (RA) and osteoarthritis (OA). Many of these solutions, however, lack scientific evidence to support their usage, and some may have harmful consequences. Therefore, the present study was carried out to screen the anti-arthritic potential of Crinum latifolium whole plant in Wistar rats. The objectives of the study was to distinguish the presence of various phytochemicals in Crinum latifolium, to evaluate the counter joint properties in vivo by formaldehyde initiated joint pain and via carrageenan-actuated paw edema strategy, and to research the non-noxious nature of Crinum latifolium by exceptional oral toxicity study in rat model.

Keywords: Rheumatoid arthritis, Crinum latifolium, Petroleum ether extract, carrageenan.