Abstract

EVALUATION OF NOOTROPIC ACTIVITY OF LEAF EXTRACT OF THE PLANT LEEA MACROPHYLLA ON EXPERIMENTAL ANIMALS

Shabana Khanam*

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Abstract

Alzheimer’s disease is identified by the appearance of excessive amounts of neurotic plaques containing amyloid β protein and loss of cholinergic markers in the brain. Cholinergic cells particularly loss at the basal forebrain is accompanied by loss of neurotransmitter i.e. acetylcholine.[1] Scopolamine-induced amnesic animal models are used to screen the agents which are claim to have a cognition activitythrough stimulation of the cholinergic system, thus making them candidate for the treatment of alzheimer’s disease. The present study was under taken to investigate the nootropic effects of Leea macrophylla on cognitive function in the experimental animals. The methonolic extract of Leea macrophylla was extracted by using soxhlet apparatus. Piracetam 200mg/kg body weight was used as a standard drug and different doses of methonolic extract of Leea macrophylla are used to evaluate its nootropic effect on Elevated plus maze and and Y maze apparatus. Fom the result it indicates that in EMP and Y maze model significantly shows the nootropic effects and also reverse scopolamine induced amnesia.

Keywords: Alzheimer’s disease, Leea macrophylla, Elevated plus Maze and Y maze.